2XE0

Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus

2XE0 の概要

• エントリーDOI: 10.2210/pdb2xe0/pdb
• 分子名称: I-CREI V2V3 VARIANT, 24MER DNA, ACETATE ION, ... (8 entities in total)
• 機能のキーワード: dna binding protein-dna complex, homing endonucleases, double-strand break, homologous recombination, human rag1 gene, severe combined immunodeficiency (scid), dna binding protein, dna binding protein/dna
• 由来する生物種: CHLAMYDOMONAS REINHARDTII; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 49192.67

構造登録者

Munoz, I.G.,Prieto, J.,Subramanian, S.,Coloma, J.,Redondo, P.,Villate, M.,Merino, N.,Marenchino, M.,D'Abramo, M.,Gervasio, F.L.,Grizot, S.,Daboussi, F.,Smith, J.,Chion-Sotine, I.,Paques, F.,Duchateau, P.,Alibes, A.,Stricher, F.,Serrano, L.,Blanco, F.J.,Montoya, G. (登録日: 2010-05-10, 公開日: 2010-09-29, 最終更新日: 2023-12-20)

• 主引用文献: Munoz, I.G.,Prieto, J.,Subramanian, S.,Coloma, J.,Redondo, P.,Villate, M.,Merino, N.,Marenchino, M.,D'Abramo, M.,Gervasio, F.L.,Grizot, S.,Daboussi, F.,Smith, J.,Chion-Sotine, I.,Paques, F.,Duchateau, P.,Alibes, A.,Stricher, F.,Serrano, L.,Blanco, F.J.,Montoya, G.; Molecular Basis of Engineered Meganuclease Targeting of the Endogenous Human Rag1 Locus; Nucleic Acids Res., 39:729-743, 2011; PubMed: 20846960; DOI: 10.1093/NAR/GKQ801

実験手法

X-RAY DIFFRACTION (2.31 Å)