2XDM

Crystal structure of a complex between Actinomadura R39 DD peptidase and a peptidoglycan mimetic boronate inhibitor

Summary for 2XDM

• Entry DOI: 10.2210/pdb2xdm/pdb
• Related: 1W79 1W8Q 1W8Y 2VGJ 2VGK 2WIX 2WKE
• Descriptor: D-ALANYL-D-ALANINE CARBOXYPEPTIDASE, SULFATE ION, COBALT (II) ION, ... (6 entities in total)
• Functional Keywords: hydrolase-inhibitor complex, boronic acid, peptidoglycan, hydrolase, hydrolase/inhibitor
• Biological source: ACTINOMADURA
• Cellular location: Secreted: P39045
• Total number of polymer chains: 4
• Total formula weight: 193466.40

Authors

Rocaboy, M.,Sauvage, E.,Herman, R.,Kerff, F.,Charlier, P. (deposition date: 2010-05-04, release date: 2010-07-21, Last modification date: 2023-12-20)

• Primary citation: Dzhekieva, L.,Rocaboy, M.,Kerff, F.,Charlier, P.,Sauvage, E.,Pratt, R.F.; Crystal Structure of a Complex between the Actinomadura R39 Dd-Peptidase and a Peptidoglycan- Mimetic Boronate Inhibitor: Interpretation of a Transition State Analogue in Terms of Catalytic Mechanism.; Biochemistry, 49:6411-, 2010; PubMed: 20608745; DOI: 10.1021/BI100757C

Experimental method

X-RAY DIFFRACTION (2.4 Å)