2XBN

Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation

2XBN の概要

• エントリーDOI: 10.2210/pdb2xbn/pdb
• 関連するPDBエントリー: 2JG2 2JGT 2W8J 2W8T 2W8U 2W8V 2W8W
• 分子名称: SERINE PALMITOYLTRANSFERASE, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: transferase, pyridoxal phosphate
• 由来する生物種: SPHINGOMONAS PAUCIMOBILIS
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46303.03

構造登録者

Lowther, J.,Yard, B.A.,Johnson, K.A.,Carter, L.G.,Bhat, V.T.,Raman, M.C.C.,Clarke, D.J.,Ramakers, B.,McMahon, S.A.,Naismith, J.H.,Campopiano, D.J. (登録日: 2010-04-13, 公開日: 2010-05-19, 最終更新日: 2024-05-08)

• 主引用文献: Lowther, J.,Yard, B.A.,Johnson, K.A.,Carter, L.G.,Bhat, V.T.,Raman, M.C.C.,Clarke, D.J.,Ramakers, B.,Mcmahon, S.A.,Naismith, J.H.,Campopiano, D.J.; Inhibition of the Plp-Dependent Enzyme Serine Palmitoyltransferase by Cycloserine: Evidence for a Novel Decarboxylative Mechanism of Inactivation.; Mol.Biosystems, 6:1682-, 2010; PubMed: 20445930; DOI: 10.1039/C003743E

実験手法

X-RAY DIFFRACTION (1.4 Å)