2XBA

Structure of Human Anaplastic Lymphoma Kinase in complex with PHA- E429

2XBA の概要

関連するPDBエントリー2XB7
分子名称ALK TYROSINE KINASE RECEPTOR, 5-[(2R)-2-hydroxy-2-phenylacetyl]-3-({[4-(4-methylpiperazin-1-yl)phenyl]carbonyl}amino)-1,6-dihydropyrrolo[3,4-c]pyrazol-5-ium (3 entities in total)
機能のキーワードatp-binding, receptor, transferase
由来する生物種HOMO SAPIENS (HUMAN)
細胞内の位置Membrane; Single-pass type I membrane protein Q9UM73
ポリマー鎖数1
分子量合計35794.14
構造登録者
Bossi, R.T.,Saccardo, M.B.,Ardini, E.,Menichincheri, M.,Rusconi, L.,Magnaghi, P.,Orsini, P.,Fogliatto, G.,Bertrand, J.A. (登録日: 2010-04-08, 公開日: 2010-07-28, 最終更新日: 2011-07-13)
主引用文献
Bossi, R.T.,Saccardo, M.B.,Ardini, E.,Menichincheri, M.,Rusconi, L.,Magnaghi, P.,Orsini, P.,Avanzi, N.,Borgia, A.L.,Nesi, M.,Bandiera, T.,Fogliatto, G.,Bertrand, J.A.
Crystal Structures of Anaplastic Lymphoma Kinase in Complex with ATP Competitive Inhibitors.
Biochemistry, 49:6813-, 2010
PubMed: 20695522 (主引用文献が同じPDBエントリー)
DOI: 10.1021/BI1005514
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.95 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.182602.0%3.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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