2X8B

Crystal structure of human acetylcholinesterase inhibited by aged tabun and complexed with fasciculin-II

2X8B の概要

• エントリーDOI: 10.2210/pdb2x8b/pdb
• 関連するPDBエントリー: 1B41 1F8U 1FSC 1FSS 1KU6 1MAH 1PUV 1PUW 1VZJ 2CLJ
• 分子名称: ACETHYLCHOLINESTERASE, FASCICULIN-2, CHLORIDE ION, ... (7 entities in total)
• 機能のキーワード: hydrolase-toxin complex, cell junction, hydrolase, gpi-anchor, neurotransmitter degradation, tabun, aging, serine esterase, blood group antigen, hydrolase/toxin
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72446.02

構造登録者

Carletti, E.,Colletier, J.P.,Nachon, F. (登録日: 2010-03-08, 公開日: 2010-04-28, 最終更新日: 2023-12-20)

• 主引用文献: Carletti, E.,Colletier, J.P.,Dupeux, F.,Trovaslet, M.,Masson, P.,Nachon, F.; Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation.; J. Med. Chem., 53:4002-4008, 2010; PubMed: 20408548; DOI: 10.1021/jm901853b

実験手法

X-RAY DIFFRACTION (2.95 Å)