2X24

bovine ACC2 CT domain in complex with inhibitor

Summary for 2X24

• Entry DOI: 10.2210/pdb2x24/pdb
• Descriptor: ACETYL-COA CARBOXYLASE, TERT-BUTYL [(TRANS-4-{[({2-[4-(AMINOMETHYL)PHENYL]QUINOLIN-4-YL}CARBONYL)AMINO]METHYL}CYCLOHEXYL)METHYL]CARBAMATE (3 entities in total)
• Functional Keywords: fatty acid biosynthesis, ligase, lipid synthesis
• Biological source: BOS TAURUS (CATTLE)
• Total number of polymer chains: 2
• Total formula weight: 179767.31

Authors

Oster, L.,Folmer, R.,Blaho, S.,Wiberg, F.,Hallberg, K. (deposition date: 2010-01-11, release date: 2011-01-26, Last modification date: 2011-07-13)

• Primary citation: Bengtsson, C.,Blaho, S.,Saitton, D.B.,Brickmann, K.,Broddefalk, J.,Davidsson, O.,Drmota, T.,Folmer, R.,Hallberg, K.,Hallen, S.,Hovland, R.,Isin, E.,Johannesson, P.,Kull, B.,Larsson, L.,Lofgren, L.,Nilsson, K.E.,Noeske, T.,Oakes, N.,Plowright, A.T.,Schnecke, V.,Stahlberg, P.,Sorme, P.,Wan, H.,Wellner, E.,Oster, L.; Design of Small Molecule Inhibitors of Acetyl-Coa Carboxylase 1 and 2 Showing Reduction of Hepatic Malonyl-Coa Levels in Vivo in Obese Zucker Rats.; Bioorg.Med.Chem., 19:3039-, 2011; PubMed: 21515056; DOI: 10.1016/J.BMC.2011.04.014

Experimental method

X-RAY DIFFRACTION (2.4 Å)