2X14

The catalytically active fully closed conformation of human phosphoglycerate kinase K219A mutant in complex with AMP-PCP and 3PG

2X14 の概要

• エントリーDOI: 10.2210/pdb2x14/pdb
• 関連するPDBエントリー: 2WZB 2WZC 2WZD 2X13 2X15 2XE6 2XE7 2XE8 2Y3I
• 分子名称: PHOSPHOGLYCERATE KINASE 1, MAGNESIUM ION, 3-PHOSPHOGLYCERIC ACID, ... (5 entities in total)
• 機能のキーワード: transition state analogue, hereditary hemolytic anemia, atp-binding, kinase, glycolysis, transferase, disease mutation
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm: P00558
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45198.89

構造登録者

Bowler, M.W.,Cliff, M.J.,Marston, J.P.M.,Baxter, N.J.,Hownslow, A.M.H.,Varga, A.V.,Szabo, J.,Vas, M.,Blackburn, G.M.,Waltho, J.P. (登録日: 2009-12-21, 公開日: 2010-12-29, 最終更新日: 2023-12-20)

• 主引用文献: Bowler, M.W.,Cliff, M.J.,Marston, J.P.M.,Baxter, N.J.,Hownslow, A.M.H.,Varga, A.V.,Szabo, J.,Vas, M.,Blackburn, G.M.,Waltho, J.P.; The Structure of Human Phosphoglycerate Kinase in its Fully Active Conformation in Complex with Ground State Analogues; To be Published,

実験手法

X-RAY DIFFRACTION (1.9 Å)