2WZZ

AMP-C BETA-LACTAMASE (PSEUDOMONAS AERUGINOSA)IN COMPLEX WITH compound M-03

2WZZ の概要

• エントリーDOI: 10.2210/pdb2wzz/pdb
• 関連するPDBエントリー: 2WZX
• 分子名称: BETA-LACTAMASE, (3R)-1-[(4R)-AZEPAN-4-YLCARBAMOYL]-3-(SULFOAMINO)-L-PROLINE, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: inhibitor, hydrolase, antibiotic resistance
• 由来する生物種: PSEUDOMONAS AERUGINOSA
• 細胞内の位置: Periplasm (By similarity): P24735
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41109.81

構造登録者

Fitzgerald, P.M.D.,Sharma, N.,Lu, J. (登録日: 2009-12-03, 公開日: 2010-01-12, 最終更新日: 2024-11-13)

主引用文献

Blizzard, T.A.,Chen, H.,Kim, S.,Wu, J.,Young, K.,Park, Y.,Ogawa, A.,Raghoobar, S.,Painter, R.E.,Hairston, N.,Lee, S.H.,Misura, A.,Felcetto, T.,Fitzgerald, P.M.D.,Sharma, N.,Lu, J.,Ha, S.,Hickey, E.,Hermes, J.,Hammond, M.L.
Side Chain Sar of Bicyclic Beta-Lactamase Inhibitors (Blis). 1. Discovery of a Class C Bli for Combination with Imipinem.
Bioorg.Med.Chem.Lett., 20:918-, 2010

PubMed Abstract: Bridged monobactam beta-lactamase inhibitors were prepared and evaluated as potential partners for combination with imipenem to overcome class C beta-lactamase mediated resistance. The (S)-azepine analog 2 was found to be effective in both in vitro and in vivo assays and was selected for preclinical development.

PubMed: 20044254
DOI: 10.1016/J.BMCL.2009.12.069

実験手法

X-RAY DIFFRACTION (1.57 Å)