2WYA

CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL 3-HYDROXY-3-METHYLGLUTARYL- COENZYME A SYNTHASE 2 (HMGCS2)

「2V4W」から置き換えられました

2WYA の概要

• エントリーDOI: 10.2210/pdb2wya/pdb
• 分子名称: HYDROXYMETHYLGLUTARYL-COA SYNTHASE, MITOCHONDRIAL, 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: steroid biosynthesis, cholesterol biosynthesis, mitochondria, mitochondrion, phosphoprotein, melavonate pathway, sterol biosynthesis, thiolase, acetylation, transferase, lipid synthesis, transit peptide, disease mutation
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Mitochondrion: P54868
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 208982.43

構造登録者

Yue, W.W.,Shafqat, N.,Savitsky, P.,Roos, A.K.,Cooper, C.,Murray, J.W.,von Delft, F.,Arrowsmith, C.,Wikstrom, M.,Edwards, A.,Bountra, C.,Oppermann, U. (登録日: 2009-11-13, 公開日: 2009-11-24, 最終更新日: 2023-12-20)

• 主引用文献: Shafqat, N.,Turnbull, A.,Zschocke, J.,Oppermann, U.,Yue, W.W.; Crystal Structures of Human Hmg-Coa Synthase Isoforms Provide Insights Into Inherited Ketogenesis Disorders and Inhibitor Design.; J.Mol.Biol., 398:497-, 2010; PubMed: 20346956; DOI: 10.1016/J.JMB.2010.03.034

実験手法

X-RAY DIFFRACTION (1.7 Å)