2WXH

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW14.

2WXH の概要

関連するPDBエントリー2WXM 2WXK 2WXL 2WXG 2WXI 2WXP 2WXO 2WXF 2WXQ 2WXN 2WXE 2WXJ 2WXR
分子名称PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM, 2-{[4-amino-3-(3-fluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-5-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one (3 entities in total)
機能のキーワードtransferase, phosphoprotein, isoform-specific inhibitors, cancer, nucleotide-binding
由来する生物種MUS MUSCULUS (MOUSE)
ポリマー鎖数1
分子量合計108331.18
構造登録者
主引用文献
Berndt, A.,Miller, S.,Williams, O.,Lee, D.D.,Houseman, B.T.,Pacold, J.I.,Gorrec, F.,Hon, W.-C.,Liu, Y.,Rommel, C.,Gaillard, P.,Ruckle, T.,Schwarz, M.K.,Shokat, K.M.,Shaw, J.P.,Williams, R.L.
The P110D Structure: Mechanisms for Selectivity and Potency of New Pi(3)K Inhibitors
Nat.Chem.Biol., 6:117-, 2010
PubMed: 20081827 (主引用文献が同じPDBエントリー)
DOI: 10.1038/NCHEMBIO.293
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.9 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliers 0.3008 0.2% 4.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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