2WV8

Complex of human dihydroorotate dehydrogenase with the inhibitor 221290

2WV8 の概要

• エントリーDOI: 10.2210/pdb2wv8/pdb
• 関連するPDBエントリー: 1D3G 1D3H 2B0M 2BXV
• 分子名称: DIHYDROOROTATE DEHYDROGENASE, MITOCHONDRIAL, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (8 entities in total)
• 機能のキーワード: flavoprotein, transmembrane, mitochondrion inner membrane, oxidoreductase, transit peptide, enzyme inhibition, pyrimidine biosynthesis, structure-based drug design, inflamation
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Mitochondrion inner membrane ; Single-pass membrane protein : Q02127
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40954.53

構造登録者

Walse, B.,Svensson, B.,Fritzson, I.,Dahlberg, L.,Wellmar, U.,Al-Karadaghi, S. (登録日: 2009-10-15, 公開日: 2010-08-25, 最終更新日: 2024-05-08)

• 主引用文献: Fritzson, I.,Svensson, B.,Al-Karadaghi, S.,Walse, B.,Wellmar, U.,Nilsson, U.J.,Da Graca Thrige, D.,Jonsson, S.; Inhibition of Human Dhodh by 4-Hydroxycoumarins, Fenamic Acids, and N-(Alkylcarbonyl)Anthranilic Acids Identified by Structure-Guided Fragment Selection.; Chemmedchem, 5:608-, 2010; PubMed: 20183850; DOI: 10.1002/CMDC.200900454

実験手法

X-RAY DIFFRACTION (1.9 Å)