2WU7

Crystal Structure of the Human CLK3 in complex with V25

Summary for 2WU7

• Entry DOI: 10.2210/pdb2wu7/pdb
• Related: 2EU9 2EXE 2WU6
• Descriptor: DUAL SPECIFICITY PROTEIN KINASE CLK3, ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate, SULFATE ION, ... (5 entities in total)
• Functional Keywords: transferase, kinase, tyrosine-protein kinase, serine/threonine-protein kinase, nucleotide-binding
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Isoform 1: Nucleus. Isoform 2: Nucleus speckle: P49761
• Total number of polymer chains: 1
• Total formula weight: 45679.47

Authors

Muniz, J.R.C.,Fedorov, O.,King, O.,Filippakopoulos, P.,Bullock, A.N.,Phillips, C.,Heightman, T.,Ugochukwu, E.,von Delft, F.,Arrowsmith, C.H.,Bracher, F.,Huber, K.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S. (deposition date: 2009-09-30, release date: 2009-10-20, Last modification date: 2011-12-07)

• Primary citation: Fedorov, O.,Huber, K.,Eisenreich, A.,Filippakopoulos, P.,King, O.,Bullock, A.N.,Szklarczyk, D.,Jensen, L.J.,Fabbro, D.,Trappe, J.,Rauch, U.,Bracher, F.,Knapp, S.; Specific Clk Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing.; Chem.Biol, 18:67-, 2011; PubMed: 21276940; DOI: 10.1016/J.CHEMBIOL.2010.11.009

Experimental method

X-RAY DIFFRACTION (2.25 Å)