2WU7

Crystal Structure of the Human CLK3 in complex with V25

2WU7 の概要

• エントリーDOI: 10.2210/pdb2wu7/pdb
• 関連するPDBエントリー: 2EU9 2EXE 2WU6
• 分子名称: DUAL SPECIFICITY PROTEIN KINASE CLK3, ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: transferase, kinase, tyrosine-protein kinase, serine/threonine-protein kinase, nucleotide-binding
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Isoform 1: Nucleus. Isoform 2: Nucleus speckle: P49761
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45679.47

構造登録者

Muniz, J.R.C.,Fedorov, O.,King, O.,Filippakopoulos, P.,Bullock, A.N.,Phillips, C.,Heightman, T.,Ugochukwu, E.,von Delft, F.,Arrowsmith, C.H.,Bracher, F.,Huber, K.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S. (登録日: 2009-09-30, 公開日: 2009-10-20, 最終更新日: 2011-12-07)

• 主引用文献: Fedorov, O.,Huber, K.,Eisenreich, A.,Filippakopoulos, P.,King, O.,Bullock, A.N.,Szklarczyk, D.,Jensen, L.J.,Fabbro, D.,Trappe, J.,Rauch, U.,Bracher, F.,Knapp, S.; Specific Clk Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing.; Chem.Biol, 18:67-, 2011; PubMed: 21276940; DOI: 10.1016/J.CHEMBIOL.2010.11.009

実験手法

X-RAY DIFFRACTION (2.25 Å)