2WU6
Crystal Structure of the Human CLK3 in complex with DKI
Summary for 2WU6
Entry DOI | 10.2210/pdb2wu6/pdb |
Related | 2EU9 2EXE 2WU7 |
Descriptor | DUAL SPECIFICITY PROTEIN KINASE CLK3, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, SULFATE ION, ... (7 entities in total) |
Functional Keywords | transferase, kinase, tyrosine-protein kinase, serine/threonine-protein kinase, nucleotide-binding |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Isoform 1: Nucleus. Isoform 2: Nucleus speckle: P49761 |
Total number of polymer chains | 1 |
Total formula weight | 46092.72 |
Authors | Muniz, J.R.C.,Fedorov, O.,King, O.,Filippakopoulos, P.,Bullock, A.N.,Philips, C.,Heightman, T.,Ugochukwu, E.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S. (deposition date: 2009-09-30, release date: 2009-10-20, Last modification date: 2024-05-08) |
Primary citation | Fedorov, O.,Huber, K.,Eisenreich, A.,Filippakopoulos, P.,King, O.,Bullock, A.N.,Szklarczyk, D.,Jensen, L.J.,Fabbro, D.,Trappe, J.,Rauch, U.,Bracher, F.,Knapp, S. Specific Clk Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing. Chem.Biol, 18:67-, 2011 Cited by PubMed: 21276940DOI: 10.1016/J.CHEMBIOL.2010.11.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.92 Å) |
Structure validation
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