2WSA

Crystal Structure of Leishmania major N-myristoyltransferase (NMT) with bound myristoyl-CoA and a pyrazole sulphonamide ligand (DDD85646)

2WSA の概要

• エントリーDOI: 10.2210/pdb2wsa/pdb
• 分子名称: GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, TETRADECANOYL-COA, 2,6-dichloro-4-(2-piperazin-1-ylpyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide, ... (4 entities in total)
• 機能のキーワード: acyltransferase, transferase, drug discovery
• 由来する生物種: LEISHMANIA MAJOR
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 52000.55

構造登録者

Robinson, D.A.,Brand, S.,Fairlamb, A.H.,Ferguson, M.A.J.,Frearson, J.A.,Wyatt, P.G.,Structural Genomics Consortium (SGC) (登録日: 2009-09-04, 公開日: 2010-03-23, 最終更新日: 2023-12-20)

• 主引用文献: Frearson, J.A.,Brand, S.,Cleghorn, L.A.T.,Mcelroy, S.,Smid, O.,Stojanovski, L.,Torrie, L.,Robinson, D.A.,Hallyburton, I.,Guther, M.L.,Price, H.P.,Mpamhanga, C.P.,Brannigan, J.A.,Hodgkinson, M.,Raimi, O.,Van Aalten, D.M.F.,Brenk, R.,Gilbert, I.H.,Read, K.D.,Fairlamb, A.H.,Ferguson, M.A.J.,Smith, D.F.,Wyatt, P.G.; N-Myristoyltransferase Inhibitors as New Leads to Treat Sleeping Sickness.; Nature, 464:728-, 2010; PubMed: 20360736; DOI: 10.1038/NATURE08893

実験手法

X-RAY DIFFRACTION (1.6 Å)