2WOW
Trypanosoma brucei trypanothione reductase with NADP and trypanothione bound
Summary for 2WOW
| Entry DOI | 10.2210/pdb2wow/pdb |
| Related | 2WOI 2WOV |
| Descriptor | TRYPANOTHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
| Functional Keywords | disulfide bond, trypanosomiasis, sleeping sickness, flavoprotein, trypanothione, oxidoreductase, fad, nadp, reductase, trypanosoma, redox-active center |
| Biological source | TRYPANOSOMA BRUCEI |
| Total number of polymer chains | 4 |
| Total formula weight | 223011.21 |
| Authors | Alphey, M.S.,Fairlamb, A.H. (deposition date: 2009-07-30, release date: 2010-08-04, Last modification date: 2023-12-20) |
| Primary citation | Patterson, S.,Alphey, M.S.,Jones, D.C.,Shanks, E.J.,Street, I.P.,Frearson, J.A.,Wyatt, P.G.,Gilbert, I.H.,Fairlamb, A.H. Dihydroquinazolines as a Novel Class of Trypanosoma Brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of Their Binding Mode by Protein Crystallography. J.Med.Chem., 54:6514-, 2011 Cited by PubMed: 21851087DOI: 10.1021/JM200312V PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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