Crystal structure of Aplysia ACHBP in complex with tropisetron

Summary for 2WNC

Related2WN9 2W8F 2BR8 2BR7 2BYR 2BYP 2BYN 2C9T 2BYS 2BYQ 2W8E 2W8G 2UZ6
DescriptorSoluble acetylcholine receptor, (3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-INDOLE-3-CARBOXYLATE (3 entities in total)
Functional Keywordscholine-binding protein, receptor, acetylcholine binding protein
Biological sourceAplysia californica (California sea hare)
Total number of polymer chains5
Total molecular weight130685.49
Sulzenbacher, G.,Hibbs, R.,Shi, J.,Talley, T.,Conrod, S.,Kem, W.,Taylor, P.,Marchot, P.,Bourne, Y. (deposition date: 2009-07-08, release date: 2009-09-01, Last modification date: 2019-04-03)
Primary citation
Hibbs, R.E.,Sulzenbacher, G.,Shi, J.,Talley, T.T.,Conrod, S.,Kem, W.R.,Taylor, P.,Marchot, P.,Bourne, Y.
Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor.
EMBO J., 28:3040-3051, 2009
PubMed: 19696737 (PDB entries with the same primary citation)
DOI: 10.1038/emboj.2009.227
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22240 3.6% 6.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution