2WMS
Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors
Summary for 2WMS
Entry DOI | 10.2210/pdb2wms/pdb |
Related | 1IA8 1NVQ 1NVR 1NVS 1ZLT 1ZYS 2AYP 2BR1 2BRB 2BRG 2BRH 2BRM 2BRN 2BRO 2C3J 2C3K 2C3L 2CGU 2CGV 2CGW 2CGX 2WMQ 2WMR 2WMT 2WMU 2WMV 2WMW 2WMX |
Descriptor | SERINE/THREONINE-PROTEIN KINASE CHK1, [4-amino-2-(tert-butylamino)-1,3-thiazol-5-yl](phenyl)methanone (3 entities in total) |
Functional Keywords | serine/threonine-protein kinase, polymorphism, phosphoprotein, ubl conjugation, isopeptide bond, checkpoint kinase, nucleotide-binding, serine/threonine kinase, dna damage, dna repair, atp-binding, transferase, chk1, kinase, nucleus, cytoplasm, cell cycle |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus: O14757 |
Total number of polymer chains | 1 |
Total formula weight | 33318.36 |
Authors | Matthews, T.P.,Klair, S.,Burns, S.,Boxall, K.,Cherry, M.,Fisher, M.,Westwood, I.M.,Walton, M.I.,McHardy, T.,Cheung, K.-M.J.,Van Montfort, R.,Williams, D.,Aherne, G.W.,Garrett, M.D.,Reader, J.,Collins, I. (deposition date: 2009-07-03, release date: 2009-07-28, Last modification date: 2023-12-13) |
Primary citation | Matthews, T.P.,Klair, S.,Burns, S.,Boxall, K.,Cherry, M.,Fisher, M.,Westwood, I.M.,Walton, M.I.,Mchardy, T.,Cheung, K.-M.J.,Van Montfort, R.,Williams, D.,Aherne, G.W.,Garrett, M.D.,Reader, J.,Collins, I. Identification of Inhibitors of Checkpoint Kinase 1 Through Template Screening. J.Med.Chem., 52:4810-, 2009 Cited by PubMed: 19572549DOI: 10.1021/JM900314J PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)