2WMC

Crystal structure of eukaryotic initiation factor 4E from Pisum sativum

2WMC の概要

• エントリーDOI: 10.2210/pdb2wmc/pdb
• 分子名称: EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE (3 entities in total)
• 機能のキーワード: biosynthetic protein, initiation factor, protein biosynthesis, eif4e, sbm1 gene, rna-binding, pisum sativum
• 由来する生物種: PISUM SATIVUM (GARDEN PEA)
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 168106.46

構造登録者

Ashby, J.A.,Stevenson, C.E.M.,Maule, A.J.,Lawson, D.M. (登録日: 2009-06-30, 公開日: 2010-09-01, 最終更新日: 2023-12-13)

主引用文献

Ashby, J.A.,Stevenson, C.E.,Jarvis, G.E.,Lawson, D.M.,Maule, A.J.
Structure-Based Mutational Analysis of Eif4E in Relation to Sbm1 Resistance to Pea Seed-Borne Mosaic Virus in Pea.
Plos One, 6:E873-, 2011

PubMed Abstract: Pea encodes eukaryotic translation initiation factor eIF4E (eIF4E(S)), which supports the multiplication of Pea seed-borne mosaic virus (PSbMV). In common with hosts for other potyviruses, some pea lines contain a recessive allele (sbm1) encoding a mutant eIF4E (eIF4E(R)) that fails to interact functionally with the PSbMV avirulence protein, VPg, giving genetic resistance to infection.

PubMed: 21283665
DOI: 10.1371/JOURNAL.PONE.0015873

実験手法

X-RAY DIFFRACTION (2.2 Å)