2WJP

CRYSTAL STRUCTURE OF MURD LIGASE IN COMPLEX WITH D-GLU CONTAINING RHODANINE INHIBITOR

Summary for 2WJP

Entry DOI	10.2210/pdb2wjp/pdb
Related	1E0D 1EEH 1UAG 2JFF 2JFG 2JFH 2UAG 2UUO 2UUP 2VTD 2VTE 3UAG 4UAG
Descriptor	UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE, N-({3-[({4-[(Z)-(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]phenyl}amino)methyl]phenyl}carbonyl)-L-glutamic acid, DIMETHYL SULFOXIDE, ... (7 entities in total)
Functional Keywords	peptidoglycan synthesis, cell wall biogenesis/degradation, cell cycle, cell division, ligase, cell shape synthesis
Biological source	ESCHERICHIA COLI DH5[ALPHA]
Cellular location	Cytoplasm: P14900
Total number of polymer chains	1
Total formula weight	48638.31
Authors	Tomasic, T.,Zidar, N.,Sink, R.,Kovac, A.,Rupnik, V.,Turk, S.,Contreras-Martel, C.,Dessen, A.,Blanot, D.,Muller-Premru, M.,Gobec, S.,Zega, A.,Peterlin-Masic, L.,Kikelj, D. (deposition date: 2009-05-28, release date: 2010-08-25, Last modification date: 2023-12-13)
Primary citation	Zidar, N.,Tomasic, T.,Sink, R.,Rupnik, V.,Kovac, A.,Turk, S.,Patin, D.,Blanot, D.,Contreras Martel, C.,Dessen, A.,Muller Premru, M.,Zega, A.,Gobec, S.,Peterlin Masic, L.,Kikelj, D. Discovery of Novel 5-Benzylidenerhodanine and 5-Benzylidenethiazolidine-2,4-Dione Inhibitors of Murd Ligase. J.Med.Chem., 53:6584-, 2010 Cited by PubMed: 20804196 DOI: 10.1021/JM100285G PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation