2WHI

Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with a purine analogue inhibitor and L-methionine-S- sulfoximine phosphate.

2WHI の概要

• エントリーDOI: 10.2210/pdb2whi/pdb
• 関連するPDBエントリー: 1HTO 1HTQ 2BVC 2WGS
• 分子名称: GLUTAMINE SYNTHETASE 1, 1-(3,4-dichlorobenzyl)-3,7-dimethyl-8-morpholin-4-yl-3,7-dihydro-1H-purine-2,6-dione, MAGNESIUM ION, ... (8 entities in total)
• 機能のキーワード: nucleotide-binding, transition state mimic, taut state, atp-binding, purine analogue, glna1, mt2278, ligase, rv2220, cytoplasm, synthetase
• 由来する生物種: MYCOBACTERIUM TUBERCULOSIS
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 334265.00

構造登録者

Nilsson, M.T.,Krajewski, W.W.,Jones, T.A.,Mowbray, S.L. (登録日: 2009-05-05, 公開日: 2009-09-01, 最終更新日: 2023-12-13)

• 主引用文献: Nilsson, M.T.,Krajewski, W.W.,Yellagunda, S.,Prabhumurthy, S.,Chamarahally, G.N.,Siddamadappa, C.,Srinivasa, B.R.,Yahiaoui, S.,Larhed, M.,Karlen, A.,Jones, T.A.,Mowbray, S.L.; Structural Basis for the Inhibition of Mycobacterium Tuberculosis Glutamine Synthetase by Novel ATP-Competitive Inhibitors.; J.Mol.Biol., 393:504-, 2009; PubMed: 19695264; DOI: 10.1016/J.JMB.2009.08.028

実験手法

X-RAY DIFFRACTION (2.2 Å)