2WHI
Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with a purine analogue inhibitor and L-methionine-S- sulfoximine phosphate.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | GLUTAMINE SYNTHETASE 1 | polymer | 486 | 54584.7 | 6 | UniProt (P0A590) Pfam (PF03951) Pfam (PF00120) UniProt (by SIFTS) (P9WN39) In PDB | MYCOBACTERIUM TUBERCULOSIS | GLUTAMATE--AMMONIA LIGASE 1 |
2 | D, A, E, B, F... | 1-(3,4-dichlorobenzyl)-3,7-dimethyl-8-morpholin-4-yl-3,7-dihydro-1H-purine-2,6-dione | non-polymer | 424.3 | 6 | Chemie (1AZ) | |||
3 | D, A, E, B, F... | MAGNESIUM ION | non-polymer | 24.3 | 18 | Chemie (MG) | |||
4 | C, D, A, E, B... | L-METHIONINE-S-SULFOXIMINE PHOSPHATE | non-polymer | 260.2 | 6 | Chemie (P3S) | |||
5 | C, D, A, E, B... | PHOSPHATE ION | non-polymer | 95.0 | 6 | Chemie (PO4) | |||
6 | F, C, D, A, E... | CHLORIDE ION | non-polymer | 35.5 | 6 | Chemie (CL) | |||
7 | F, C, D, A, E... | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 6 | Chemie (1PE) | |||
8 | water | water | 18.0 | 1649 | Chemie (HOH) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 327508.4 | |
Non-Polymers* | Number of molecules | 48 |
Total formula weight | 6756.6 | |
All* | Total formula weight | 334265.0 |