2WH6

Crystal structure of anti-apoptotic BHRF1 in complex with the Bim BH3 domain

Summary for 2WH6

• Entry DOI: 10.2210/pdb2wh6/pdb
• Related: 1Q59 2V6Q 2VM6
• Descriptor: EARLY ANTIGEN PROTEIN R, BCL-2-LIKE PROTEIN 11, BROMIDE ION, ... (5 entities in total)
• Functional Keywords: mitochondrion, early protein, transmembrane, viral protein, apoptosis
• Biological source: Epstein-barr virus strain ag876; More
• Cellular location: Host membrane ; Single-pass membrane protein : P03182; Endomembrane system ; Peripheral membrane protein . Isoform BimEL: Mitochondrion. Isoform BimL: Mitochondrion. Isoform BimS: Mitochondrion. Isoform Bim-alpha1: Mitochondrion: O43521
• Total number of polymer chains: 2
• Total formula weight: 24026.38

Authors

Kvansakul, M.,Huang, D.C.S.,Colman, P.M. (deposition date: 2009-05-01, release date: 2010-05-26, Last modification date: 2023-12-13)

• Primary citation: Kvansakul, M.,Wei, A.H.,Fletcher, J.I.,Willis, S.N.,Chen, L.,Roberts, A.W.,Huang, D.C.,Colman, P.M.; Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1.; PLoS Pathog., 6:e1001236-e1001236, 2010; PubMed: 21203485; DOI: 10.1371/journal.ppat.1001236

Experimental method

X-RAY DIFFRACTION (1.5 Å)