2WFN

Filamin A actin binding domain

2WFN の概要

• エントリーDOI: 10.2210/pdb2wfn/pdb
• 関連するPDBエントリー: 2AAV 2BP3 2BRQ 2J3S 2JF1 2W0P
• 分子名称: FILAMIN-A, SULFATE ION (3 entities in total)
• 機能のキーワード: contractile protein, phosphoprotein, disease mutation, cytoplasm, alternative splicing, cytoskeleton, actin-binding, polymorphism, acetylation
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm, cell cortex: P21333
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 63175.73

構造登録者

Ruskamo, S.,Ylanne, J. (登録日: 2009-04-09, 公開日: 2009-10-27, 最終更新日: 2023-12-13)

主引用文献

Ruskamo, S.,Ylanne, J.
Structure of the Human Filamin a Actin-Binding Domain
Acta Crystallogr.,Sect.D, 65:1217-, 2009

PubMed Abstract: Filamin A (FLNa) is a large dimeric protein that binds to actin filaments via its actin-binding domain (ABD). The crystal structure of this domain was solved at 3.2 A resolution. The domain adopts a closed conformation typical of other ABDs, but also forms a dimer both in crystallization conditions and in solution. The structure shows the localization of the residues mutated in patients with periventricular nodular heterotopia or otopalatodigital syndrome. Structural analysis predicts that mutations in both types of disorder may affect actin binding.

PubMed: 19923718
DOI: 10.1107/S0907444909037330

実験手法

X-RAY DIFFRACTION (3.2 Å)