2WEY
Human PDE-papaverine complex obtained by ligand soaking of cross- linked protein crystals
Summary for 2WEY
Entry DOI | 10.2210/pdb2wey/pdb |
Related | 1LRB |
Descriptor | CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE, 1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXYISOQUINOLINE, ZINC ION, ... (5 entities in total) |
Functional Keywords | metal-binding, cross-linking, phosphoprotein, phosphodiesterase, allosteric enzyme, cgmp, camp, zinc, hydrolase, cytoplasm, magnesium, papaverine, polymorphism, cgmp-binding, camp-binding, nucleotide-binding, alternative splicing |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm: Q9Y233 |
Total number of polymer chains | 2 |
Total formula weight | 79782.80 |
Authors | Andersen, O.A.,Schonfeld, D.L.,Toogood-Johnson, I.,Felicetti, B.,Albrecht, C.,Fryatt, T.,Whittaker, M.,Hallett, D.,Barker, J. (deposition date: 2009-04-02, release date: 2009-07-28, Last modification date: 2024-01-31) |
Primary citation | Andersen, O.A.,Schonfeld, D.L.,Toogood-Johnson, I.,Felicetti, B.,Albrecht, C.,Fryatt, T.,Whittaker, M.,Hallett, D.,Barker, J. Cross-Linking of Protein Crystals as an Aid in the Generation of Binary Protein-Ligand Crystal Complexes, Exemplified by the Human Pde10A-Papaverine Structure. Acta Crystallogr.,Sect.D, 65:872-, 2009 Cited by PubMed: 19622871DOI: 10.1107/S0907444909017855 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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