2WEY

Human PDE-papaverine complex obtained by ligand soaking of cross- linked protein crystals

2WEY の概要

• エントリーDOI: 10.2210/pdb2wey/pdb
• 関連するPDBエントリー: 1LRB
• 分子名称: CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE, 1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXYISOQUINOLINE, ZINC ION, ... (5 entities in total)
• 機能のキーワード: metal-binding, cross-linking, phosphoprotein, phosphodiesterase, allosteric enzyme, cgmp, camp, zinc, hydrolase, cytoplasm, magnesium, papaverine, polymorphism, cgmp-binding, camp-binding, nucleotide-binding, alternative splicing
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm: Q9Y233
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 79782.80

構造登録者

Andersen, O.A.,Schonfeld, D.L.,Toogood-Johnson, I.,Felicetti, B.,Albrecht, C.,Fryatt, T.,Whittaker, M.,Hallett, D.,Barker, J. (登録日: 2009-04-02, 公開日: 2009-07-28, 最終更新日: 2024-01-31)

• 主引用文献: Andersen, O.A.,Schonfeld, D.L.,Toogood-Johnson, I.,Felicetti, B.,Albrecht, C.,Fryatt, T.,Whittaker, M.,Hallett, D.,Barker, J.; Cross-Linking of Protein Crystals as an Aid in the Generation of Binary Protein-Ligand Crystal Complexes, Exemplified by the Human Pde10A-Papaverine Structure.; Acta Crystallogr.,Sect.D, 65:872-, 2009; PubMed: 19622871; DOI: 10.1107/S0907444909017855

実験手法

X-RAY DIFFRACTION (2.8 Å)