2WEI

Crystal structure of the kinase domain of Cryptosporidium parvum calcium dependent protein kinase in complex with 3-MB-PP1

Summary for 2WEI

• Entry DOI: 10.2210/pdb2wei/pdb
• Descriptor: CALMODULIN-DOMAIN PROTEIN KINASE 1, PUTATIVE, 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3 entities in total)
• Functional Keywords: nucleotide-binding, serine/threonine-protein kinase, kinase, transferase, atp-binding
• Biological source: CRYPTOSPORIDIUM PARVUM IOWA II
• Total number of polymer chains: 1
• Total formula weight: 33740.78

Authors

Roos, A.K.,King, O.,Chaikuad, A.,Zhang, C.,Shokat, K.M.,Wernimont, A.K.,Artz, J.D.,Lin, L.,MacKenzie, F.I.,Finerty, P.J.,Vedadi, M.,Schapira, M.,Indarte, M.,Kozieradzki, I.,Pike, A.C.W.,Fedorov, O.,Doyle, D.,Muniz, J.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,Bountra, C.,von Delft, F.,Heightman, T.,Hui, R. (deposition date: 2009-03-31, release date: 2009-04-28, Last modification date: 2023-12-13)

Primary citation

Artz, J.D.,Wernimont, A.K.,Allali-Hassani, A.,Zhao, Y.,Amani, M.,Lin, Y.H.,Senisterra, G.,Wasney, G.A.,Fedorov, O.,King, O.,Roos, A.K.,Lunin, V.V.,Qiu, W.,Finerty, P.J.,Hutchinson, A.,Chau, I.,von Delft, F.,MacKenzie, F.I.,Lew, J.,Kozieradzki, I.,Vedadi, M.,Schapira, M.,Zhang, C.,Shokat, K.M.,Heightman, T.,Hui, R.
The Cryptosporidium Parvum Kinome.
Bmc Genomics, 12:478-, 2011

PubMed Abstract: Hundreds of millions of people are infected with cryptosporidiosis annually, with immunocompromised individuals suffering debilitating symptoms and children in socioeconomically challenged regions at risk of repeated infections. There is currently no effective drug available. In order to facilitate the pursuit of anti-cryptosporidiosis targets and compounds, our study spans the classification of the Cryptosporidium parvum kinome and the structural and biochemical characterization of representatives from the CDPK family and a MAP kinase.

PubMed: 21962082
DOI: 10.1186/1471-2164-12-478

Experimental method

X-RAY DIFFRACTION (1.65 Å)