2WEI

Crystal structure of the kinase domain of Cryptosporidium parvum calcium dependent protein kinase in complex with 3-MB-PP1

2WEI の概要

• エントリーDOI: 10.2210/pdb2wei/pdb
• 分子名称: CALMODULIN-DOMAIN PROTEIN KINASE 1, PUTATIVE, 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3 entities in total)
• 機能のキーワード: nucleotide-binding, serine/threonine-protein kinase, kinase, transferase, atp-binding
• 由来する生物種: CRYPTOSPORIDIUM PARVUM IOWA II
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33740.78

構造登録者

Roos, A.K.,King, O.,Chaikuad, A.,Zhang, C.,Shokat, K.M.,Wernimont, A.K.,Artz, J.D.,Lin, L.,MacKenzie, F.I.,Finerty, P.J.,Vedadi, M.,Schapira, M.,Indarte, M.,Kozieradzki, I.,Pike, A.C.W.,Fedorov, O.,Doyle, D.,Muniz, J.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,Bountra, C.,von Delft, F.,Heightman, T.,Hui, R. (登録日: 2009-03-31, 公開日: 2009-04-28, 最終更新日: 2023-12-13)

主引用文献

Artz, J.D.,Wernimont, A.K.,Allali-Hassani, A.,Zhao, Y.,Amani, M.,Lin, Y.H.,Senisterra, G.,Wasney, G.A.,Fedorov, O.,King, O.,Roos, A.K.,Lunin, V.V.,Qiu, W.,Finerty, P.J.,Hutchinson, A.,Chau, I.,von Delft, F.,MacKenzie, F.I.,Lew, J.,Kozieradzki, I.,Vedadi, M.,Schapira, M.,Zhang, C.,Shokat, K.M.,Heightman, T.,Hui, R.
The Cryptosporidium Parvum Kinome.
Bmc Genomics, 12:478-, 2011

PubMed Abstract: Hundreds of millions of people are infected with cryptosporidiosis annually, with immunocompromised individuals suffering debilitating symptoms and children in socioeconomically challenged regions at risk of repeated infections. There is currently no effective drug available. In order to facilitate the pursuit of anti-cryptosporidiosis targets and compounds, our study spans the classification of the Cryptosporidium parvum kinome and the structural and biochemical characterization of representatives from the CDPK family and a MAP kinase.

PubMed: 21962082
DOI: 10.1186/1471-2164-12-478

実験手法

X-RAY DIFFRACTION (1.65 Å)