2WCN
Solution structure of an LNA-modified quadruplex
Summary for 2WCN
| Entry DOI | 10.2210/pdb2wcn/pdb |
| Descriptor | DNA (5'-D(*DGP*LCG*DGP*LCG*DTP*DTP*DTP *DTP*DGP*LCG*DGP*LCG)-3') (1 entity in total) |
| Functional Keywords | lna, quadruplex, folding topology, dna |
| Biological source | OXYTRICHA NOVA |
| Total number of polymer chains | 2 |
| Total formula weight | 7835.00 |
| Authors | Nielsen, J.T.,Arar, K.,Petersen, M. (deposition date: 2009-03-12, release date: 2009-11-24, Last modification date: 2024-05-15) |
| Primary citation | Nielsen, J.T.,Arar, K.,Petersen, M. Solution Structure of a Locked Nucleic Acid Modified Quadruplex: Introducing the V4 Folding Topology. Angew.Chem.Int.Ed.Engl., 48:3099-, 2009 Cited by PubMed Abstract: Sharp curves: The structure of a locked nucleic acid modified telomeric sequence from Oxytricha nova displays a remarkable folding topology, distinct from the native O. nova quadruplex. Each guanine stretch folds back in a V-shaped turn that puts the first and fourth guanines in the same tetrad, looping over a tetrad with a sharp turn in the DNA backbone, showing how subtle interplay between sequence and conformation defines the folding topology. PubMed: 19308940DOI: 10.1002/ANIE.200806244 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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