2WBM

Crystal structure of mthSBDS, the homologue of the Shwachman-Bodian- Diamond syndrome protein in the euriarchaeon Methanothermobacter thermautotrophicus

Summary for 2WBM

• Entry DOI: 10.2210/pdb2wbm/pdb
• Descriptor: RIBOSOME MATURATION PROTEIN SDO1 HOMOLOG, GLYCEROL, SULFATE ION, ... (5 entities in total)
• Functional Keywords: shwachman-bodian-diamond syndrome protein, ribosome binding, conformational flexibility, rna-binding protein, rna binding protein
• Biological source: METHANOTHERMOBACTER THERMAUTOTROPHICUS
• Total number of polymer chains: 2
• Total formula weight: 57630.94

Authors

Ng, C.L.,Isupov, M.N.,Lebedev, A.A.,Ortiz-Lombardia, M.,Antson, A.A. (deposition date: 2009-03-02, release date: 2009-06-02, Last modification date: 2023-12-13)

Primary citation

Ng, C.L.,Waterman, D.G.,Koonin, E.V.,Walters, A.D.,Chong, J.P.,Isupov, M.N.,Lebedev, A.A.,Bunka, D.H.,Stockley, P.G.,Ortiz-Lombardia, M.,Antson, A.A.
Conformational Flexibility and Molecular Interactions of an Archaeal Homologue of the Shwachman-Bodian-Diamond Syndrome Protein.
Bmc Struct.Biol., 9:32-, 2009

PubMed Abstract: Defects in the human Shwachman-Bodian-Diamond syndrome (SBDS) protein-coding gene lead to the autosomal recessive disorder characterised by bone marrow dysfunction, exocrine pancreatic insufficiency and skeletal abnormalities. This protein is highly conserved in eukaryotes and archaea but is not found in bacteria. Although genomic and biophysical studies have suggested involvement of this protein in RNA metabolism and in ribosome biogenesis, its interacting partners remain largely unknown.

PubMed: 19454024
DOI: 10.1186/1472-6807-9-32

Experimental method

X-RAY DIFFRACTION (1.75 Å)