2WAP

3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with the drug-like urea inhibitor PF-3845

2WAP の概要

• エントリーDOI: 10.2210/pdb2wap/pdb
• 関連するPDBエントリー: 1MT5 2VYA
• 分子名称: FATTY-ACID AMIDE HYDROLASE 1, 4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzyl)piperidine-1-carboxylic acid, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: fatty acid amide hydrolase, urea inhibitor, golgi apparatus, endoplasmic reticulum, acyl- enzyme, transmembrane, phosphoprotein, faah, drug, membrane, hydrolase, inhibitor
• 由来する生物種: RATTUS NORVEGICUS (RAT)
• 細胞内の位置: Endoplasmic reticulum membrane; Single-pass membrane protein: P97612
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 120519.18

構造登録者

Mileni, M.,Kamtekar, S.,Stevens, R.C. (登録日: 2009-02-11, 公開日: 2009-05-05, 最終更新日: 2023-12-13)

• 主引用文献: Ahn, K.,Johnson, D.S.,Mileni, M.,Beidler, D.,Long, J.Z.,Mckinney, M.K.,Weerapana, E.,Sadagopan, N.,Liimatta, M.,Smith, S.E.,Lazerwith, S.,Stiff, C.,Kamtekar, S.,Bhattacharya, K.,Zhang, Y.,Swaney, S.,Vanbecelaere, K.,Stevens, R.C.,Cravatt, B.F.; Discovery and Characterization of a Highly Selective Faah Inhibitor that Reduces Inflammatory Pain.; Chem.Biol., 16:411-, 2009; PubMed: 19389627; DOI: 10.1016/J.CHEMBIOL.2009.02.013

実験手法

X-RAY DIFFRACTION (2.8 Å)