2WA7
Structure of the M202V mutant of human filamin b actin binding domain at 1.85 Angstrom resolution
Summary for 2WA7
Entry DOI | 10.2210/pdb2wa7/pdb |
Related | 2DI8 2DI9 2DIA 2DIB 2DIC 2DJ4 2WA5 2WA6 |
Descriptor | FILAMIN-B, CACODYLATE ION, CARBONATE ION, ... (4 entities in total) |
Functional Keywords | disease mutation, skeletal dysplasia, structural protein, actin-crosslinking, myogenesis, cytoskeleton, actin-binding, calponin homology domain, phosphoprotein, differentiation, atelosteogenesis, mutant, filamin, dwarfism, ch domain, developmental protein |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Isoform 1: Cytoplasm, cell cortex. Isoform 2: Cytoplasm, cytoskeleton. Isoform 3: Cytoplasm, cytoskeleton. Isoform 6: Cytoplasm, cytoskeleton: O75369 |
Total number of polymer chains | 1 |
Total formula weight | 28420.14 |
Authors | Sawyer, G.M.,Clark, A.R.,Robertson, S.P.,Sutherland-Smith, A.J. (deposition date: 2009-02-03, release date: 2009-06-23, Last modification date: 2023-12-13) |
Primary citation | Sawyer, G.M.,Clark, A.R.,Robertson, S.P.,Sutherland-Smith, A.J. Disease-Associated Substitutions in the Filamin B Actin Binding Domain Confer Enhanced Actin Binding Affinity in the Absence of Major Structural Disturbance: Insights from the Crystal Structures of Filamin B Actin Binding Domains. J.Mol.Biol., 390:1030-, 2009 Cited by PubMed: 19505475DOI: 10.1016/J.JMB.2009.06.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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