2WA6

Structure of the W148R mutant of human filamin b actin binding domain at 1.95 Angstrom resolution

Summary for 2WA6

Entry DOI	10.2210/pdb2wa6/pdb
Related	2DI8 2DI9 2DIA 2DIB 2DIC 2DJ4 2WA5 2WA7
Descriptor	FILAMIN-B, CARBONATE ION (3 entities in total)
Functional Keywords	disease mutation, skeletal dysplasia, structural protein, actin-crosslinking, myogenesis, cytoskeleton, actin-binding, calponin homology domain, phosphoprotein, differentiation, atelosteogenesis, mutant, filamin, dwarfism, ch domain, developmental protein
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Isoform 1: Cytoplasm, cell cortex. Isoform 2: Cytoplasm, cytoskeleton. Isoform 3: Cytoplasm, cytoskeleton. Isoform 6: Cytoplasm, cytoskeleton: O75369
Total number of polymer chains	1
Total formula weight	28226.19
Authors	Sawyer, G.M.,Clark, A.R.,Robertson, S.P.,Sutherland-Smith, A.J. (deposition date: 2009-02-03, release date: 2009-06-23, Last modification date: 2023-12-13)
Primary citation	Sawyer, G.M.,Clark, A.R.,Robertson, S.P.,Sutherland-Smith, A.J. Disease-Associated Substitutions in the Filamin B Actin Binding Domain Confer Enhanced Actin Binding Affinity in the Absence of Major Structural Disturbance: Insights from the Crystal Structures of Filamin B Actin Binding Domains. J.Mol.Biol., 390:1030-, 2009 Cited by PubMed: 19505475 DOI: 10.1016/J.JMB.2009.06.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation