2WA6

Structure of the W148R mutant of human filamin b actin binding domain at 1.95 Angstrom resolution

2WA6 の概要

• エントリーDOI: 10.2210/pdb2wa6/pdb
• 関連するPDBエントリー: 2DI8 2DI9 2DIA 2DIB 2DIC 2DJ4 2WA5 2WA7
• 分子名称: FILAMIN-B, CARBONATE ION (3 entities in total)
• 機能のキーワード: disease mutation, skeletal dysplasia, structural protein, actin-crosslinking, myogenesis, cytoskeleton, actin-binding, calponin homology domain, phosphoprotein, differentiation, atelosteogenesis, mutant, filamin, dwarfism, ch domain, developmental protein
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Isoform 1: Cytoplasm, cell cortex. Isoform 2: Cytoplasm, cytoskeleton. Isoform 3: Cytoplasm, cytoskeleton. Isoform 6: Cytoplasm, cytoskeleton: O75369
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28226.19

構造登録者

Sawyer, G.M.,Clark, A.R.,Robertson, S.P.,Sutherland-Smith, A.J. (登録日: 2009-02-03, 公開日: 2009-06-23, 最終更新日: 2023-12-13)

• 主引用文献: Sawyer, G.M.,Clark, A.R.,Robertson, S.P.,Sutherland-Smith, A.J.; Disease-Associated Substitutions in the Filamin B Actin Binding Domain Confer Enhanced Actin Binding Affinity in the Absence of Major Structural Disturbance: Insights from the Crystal Structures of Filamin B Actin Binding Domains.; J.Mol.Biol., 390:1030-, 2009; PubMed: 19505475; DOI: 10.1016/J.JMB.2009.06.009

実験手法

X-RAY DIFFRACTION (1.95 Å)