2W99

Crystal Structure of CDK4 in complex with a D-type cyclin

Summary for 2W99

• Entry DOI: 10.2210/pdb2w99/pdb
• Related: 1LD2 2W96
• Descriptor: G1/S-SPECIFIC CYCLIN-D1, CELL DIVISION PROTEIN KINASE 4 (3 entities in total)
• Functional Keywords: serine/threonine-protein kinase, chromosomal rearrangement, atp-binding, transferase, polymorphism, cell division, proto-oncogene, phosphoprotein, disease mutation, nucleotide-binding, cyclin dependent kinase, kinase, cyclin, oncology, cell cycle, drug desgn
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 2
• Total formula weight: 65534.93

Authors

Day, P.J.,Cleasby, A.,Tickle, I.J.,Reilly, M.O.,Coyle, J.E.,Holding, F.P.,McMenamin, R.L.,Yon, J.,Chopra, R.,Lengauer, C.,Jhoti, H. (deposition date: 2009-01-22, release date: 2009-03-10, Last modification date: 2023-12-13)

• Primary citation: Day, P.J.,Cleasby, A.,Tickle, I.J.,O'Reilly, M.,Coyle, J.E.,Holding, F.P.,Mcmenamin, R.L.,Yon, J.,Chopra, R.,Lengauer, C.,Jhoti, H.; Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin.; Proc.Natl.Acad.Sci.USA, 106:4166-, 2009; PubMed: 19237565; DOI: 10.1073/PNAS.0809645106

Experimental method

X-RAY DIFFRACTION (2.8 Å)