2W8M

Structure of D212, a nuclease from a fusselovirus.

2W8M の概要

• エントリーDOI: 10.2210/pdb2w8m/pdb
• 分子名称: ORF D212 (2 entities in total)
• 機能のキーワード: ssv1, crenarchaeal virus, hydrolase
• 由来する生物種: SULFOLOBUS VIRUS RAGGED HILLS
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50213.44

構造登録者

Menon, S.K.,Young, M.J.,Lawrence, C.M. (登録日: 2009-01-17, 公開日: 2009-02-03, 最終更新日: 2024-05-08)

主引用文献

Menon, S.K.,Eilers, B.J.,Young, M.J.,Lawrence, C.M.
The crystal structure of D212 from sulfolobus spindle-shaped virus ragged hills reveals a new member of the PD-(D/E)XK nuclease superfamily.
J. Virol., 84:5890-5897, 2010

PubMed Abstract: Structural studies have made significant contributions to our understanding of Sulfolobus spindle-shaped viruses (Fuselloviridae), an important model system for archaeal viruses. Continuing these efforts, we report the structure of D212 from Sulfolobus spindle-shaped virus Ragged Hills. The overall fold and conservation of active site residues place D212 in the PD-(D/E)XK nuclease superfamily. The greatest structural similarity is found to the archaeal Holliday junction cleavage enzymes, strongly suggesting a role in DNA replication, repair, or recombination. Other roles associated with nuclease activity are also considered.

PubMed: 20375162
DOI: 10.1128/JVI.01663-09

実験手法

X-RAY DIFFRACTION (2.4 Å)