2W7X

Cellular inhibition of checkpoint kinase 2 and potentiation of cytotoxic drugs by novel Chk2 inhibitor PV1019

2W7X の概要

• エントリーDOI: 10.2210/pdb2w7x/pdb
• 関連するPDBエントリー: 1GXC 2CN5 2CN8 2W0J
• 分子名称: SERINE/THREONINE-PROTEIN KINASE CHK2, N-[4-[(E)-N-carbamimidamido-C-methyl-carbonimidoyl]phenyl]-7-nitro-1H-indole-2-carboxamide, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: co-crystal structure, kinase, nucleus, magnesium, cell cycle, atp-binding, li-fraumeni syndrome, serine/threonine-protein kinase, disease mutation, nucleotide-binding, transferase, potentiation, metal-binding, proto-oncogene, phosphoprotein, chk2 inhibitor
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Isoform 2: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus. Nucleus, PML body: O96017
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37152.06

構造登録者

Jobson, A.G.,Lountos, G.T.,Lorenzi, P.L.,Llamas, J.,Connelly, J.,Tropea, J.E.,Onda, A.,Kondapaka, S.,Zhang, G.,Caplen, N.J.,Caredellina, J.H.,Monks, A.,Self, C.,Waugh, D.S.,Shoemaker, R.H.,Pommier, Y. (登録日: 2009-01-06, 公開日: 2009-09-22, 最終更新日: 2023-12-13)

• 主引用文献: Jobson, A.G.,Lountos, G.T.,Lorenzi, P.L.,Llamas, J.,Connelly, J.,Cerna, D.,Tropea, J.E.,Onda, A.,Zoppoli, G.,Kondapaka, S.,Zhang, G.,Caplen, N.J.,Cardellina, J.H.,Yoo, S.S.,Monks, A.,Self, C.,Waugh, D.S.,Shoemaker, R.H.,Pommier, Y.; Cellular Inhibition of Chk2 Kinase and Potentiation of Camptothecins and Radiation by the Novel Chk2 Inhibitor Pv1019.; J.Pharmacol.Exp.Ther., 331:816-, 2009; PubMed: 19741151; DOI: 10.1124/JPET.109.154997

実験手法

X-RAY DIFFRACTION (2.07 Å)