2W4I

Crystal structure of Helicobacter pylori glutamate racemase in complex with D-Glutamate and an inhibitor

Summary for 2W4I

Entry DOI	10.2210/pdb2w4i/pdb
Related	2JFX 2JFY 2JFZ
Descriptor	GLUTAMATE RACEMASE, D-GLUTAMIC ACID, 1-[(3S)-5-PHENYL-3-THIOPHEN-2-YL-3H-1,4-BENZODIAZEPIN-2-YL]AZETIDIN-3-OL, ... (4 entities in total)
Functional Keywords	isomerase, cell shape, glutamate racemase, cell wall biogenesis/degradation, peptidoglycan synthesis, peptidoglycan biosynthesis
Biological source	HELICOBACTER PYLORI
Total number of polymer chains	4
Total formula weight	115464.23
Authors	Lundqvist, T. (deposition date: 2008-11-25, release date: 2008-12-09, Last modification date: 2023-12-13)
Primary citation	Geng, B.,Basarab, G.,Comita-Prevoir, J.,Gowravaram, M.,Hill, P.,Kiely, A.,Loch, J.,MacPherson, L.,Morningstar, M.,Mullen, G.,Osimboni, E.,Satz, A.,Eyermann, C.,Lundqvist, T. Potent and selective inhibitors of Helicobacter pylori glutamate racemase (MurI): pyridodiazepine amines. Bioorg. Med. Chem. Lett., 19:930-936, 2009 Cited by PubMed: 19097892 DOI: 10.1016/j.bmcl.2008.11.113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.87 Å)

Structure validation