2W3N

Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans

2W3N の概要

• エントリーDOI: 10.2210/pdb2w3n/pdb
• 分子名称: CARBONIC ANHYDRASE 2, ZINC ION, ACETATE ION, ... (5 entities in total)
• 機能のキーワード: beta-class carbonic anhydrase, lyase, inhibition, sulfonamide, cryptococcus neoformans
• 由来する生物種: CRYPTOCOCCUS NEOFORMANS
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 80359.01

構造登録者

Schlicker, C.,Hall, R.A.,Vullo, D.,Middelhaufe, S.,Gertz, M.,Supuran, C.T.,Muehlschlegel, F.A.,Steegborn, C. (登録日: 2008-11-13, 公開日: 2008-12-30, 最終更新日: 2023-12-13)

• 主引用文献: Schlicker, C.,Hall, R.A.,Vullo, D.,Middelhaufe, S.,Gertz, M.,Supuran, C.T.,Muhlschlegel, F.A.,Steegborn, C.; Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans.; J. Mol. Biol., 385:1207-1220, 2009; PubMed: 19071134; DOI: 10.1016/j.jmb.2008.11.037

実験手法

X-RAY DIFFRACTION (2.05 Å)