2W2Q
PCSK9-deltaC D374H mutant bound to WT EGF-A of LDLR
Summary for 2W2Q
Entry DOI | 10.2210/pdb2w2q/pdb |
Related | 1AJJ 1D2J 1F5Y 1F8Z 1HJ7 1HZ8 1I0U 1IJQ 1LDL 1LDR 1LRX 1N7D 1XFE 2FCW 2W2M 2W2N 2W2O 2W2P |
Descriptor | PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9, LOW-DENSITY LIPOPROTEIN RECEPTOR, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | hydrolase-receptor complex, pcsk9, ldlr, proprotein convertase, low-density lipoprotein receptor, egf, cardiovascular disease, familial hypercholesterolemia, lipid metabolism, serine protease, hydrolase, lipid transport, steroid metabolism, receptor, hydrolase/receptor |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Secreted: Q8NBP7 Cell membrane; Single-pass type I membrane protein: Q8NBP7 |
Total number of polymer chains | 3 |
Total formula weight | 57986.50 |
Authors | Bottomley, M.J.,Cirillo, A.,Orsatti, L.,Ruggeri, L.,Fisher, T.S.,Santoro, J.C.,Cummings, R.T.,Cubbon, R.M.,Lo Surdo, P.,Calzetta, A.,Noto, A.,Baysarowich, J.,Mattu, M.,Talamo, F.,De Francesco, R.,Sparrow, C.P.,Sitlani, A.,Carfi, A. (deposition date: 2008-11-03, release date: 2008-11-18, Last modification date: 2023-12-13) |
Primary citation | Bottomley, M.J.,Cirillo, A.,Orsatti, L.,Ruggeri, L.,Fisher, T.S.,Santoro, J.C.,Cummings, R.T.,Cubbon, R.M.,Lo Surdo, P.,Calzetta, A.,Noto, A.,Baysarowich, J.,Mattu, M.,Talamo, F.,De Francesco, R.,Sparrow, C.P.,Sitlani, A.,Carfi, A. Structural and Biochemical Characterization of the Wild Type Pcsk9/Egf-Ab Complex and Natural Fh Mutants. J.Biol.Chem., 284:1313-, 2009 Cited by PubMed: 19001363DOI: 10.1074/JBC.M808363200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.33 Å) |
Structure validation
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