2W2Q

PCSK9-deltaC D374H mutant bound to WT EGF-A of LDLR

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9	polymer	312	33131.3	1	UniProt (Q8NBP7) Pfam (PF00082)	HOMO SAPIENS (HUMAN)	PCSK9, PROPROTEIN CONVERTASE PC9, SUBTILISIN/KEXIN-LIKE PROTEASE PC9, NEURAL APOPTOSIS-REGULATED CONVERTASE 1, NARC-1
2	B (E)	LOW-DENSITY LIPOPROTEIN RECEPTOR	polymer	107	12095.5	1	UniProt (P01130)	HOMO SAPIENS (HUMAN)	LDL RECEPTOR
3	C (P)	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9	polymer	114	12679.6	1	UniProt (Q8NBP7) Pfam (PF05922)	HOMO SAPIENS (HUMAN)	PCSK9, PROPROTEIN CONVERTASE PC9, SUBTILISIN/KEXIN-LIKE PROTEASE PC9, NEURAL APOPTOSIS-REGULATED CONVERTASE 1, NARC-1
4	D, E (A, E)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
5	F, G, H (A, E, P)	water	water		18.0	195	Chemie (HOH)

Sequence modifications

P: 39 - 52 (PDB: 2W2Q)
P: 53 - 152 (UniProt: Q8NBP7)
A: 153 - 451 (UniProt: Q8NBP7)

PDB	External Database	Details
His 374	Asp 374	engineered mutation

A: 452 - 464 (PDB: 2W2Q)
E: 266 - 292 (PDB: 2W2Q)
E: 293 - 372 (UniProt: P01130)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	57906.3
Non-Polymers*	Number of molecules	2
	Total formula weight	80.2
All*	Total formula weight	57986.5

*Water molecules are not included.