2W1B

The structure of the efflux pump AcrB in complex with bile acid

2W1B の概要

• エントリーDOI: 10.2210/pdb2w1b/pdb
• 関連するPDBエントリー: 1IWG 1OY6 1OY8 1OY9 1OYD 1OYE 1T9T 1T9U 1T9V 1T9W 1T9X 1T9Y 2GIF 2HRT 2J8S
• 分子名称: ACRIFLAVIN RESISTANCE PROTEIN B, (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID (2 entities in total)
• 機能のキーワード: membrane protein, multidrug efflux, membrane, transport, transporter
• 由来する生物種: ESCHERICHIA COLI
• 細胞内の位置: Cell inner membrane; Multi-pass membrane protein: P31224
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 114057.75

構造登録者

Drew, D.,Klepsch, M.M.,Newstead, S.,Flaig, R.,De Gier, J.W.,Iwata, S.,Beis, K. (登録日: 2008-10-17, 公開日: 2008-12-09, 最終更新日: 2023-12-13)

主引用文献

Drew, D.,Klepsch, M.M.,Newstead, S.,Flaig, R.,De Gier, J.W.,Iwata, S.,Beis, K.
The Structure of the Efflux Pump Acrb in Complex with Bile Acid.
Mol.Membr.Biol., 25:677-, 2008

PubMed Abstract: Gastrointestinal bacteria, like Escherichia coli, must remove bile acid to survive in the gut. Bile acid removal in E. coli is thought to be mediated primarily by the multidrug efflux pump, AcrB. Here, we present the structure of E. coli AcrB in complex with deoxycholate at 3.85 A resolution. All evidence suggests that bile acid is transported out of the cell via the periplasmic vestibule of the AcrAB-TolC complex.

PubMed: 19023693
DOI: 10.1080/09687680802552257

実験手法

X-RAY DIFFRACTION (3.85 Å)