2W14

High-resolution crystal structure of the P-I snake venom metalloproteinase BaP1 in complex with a peptidomimetic: insights into inhibitor binding

Summary for 2W14

Entry DOI	10.2210/pdb2w14/pdb
Related	1ND1 2W12 2W13 2W15
Descriptor	ZINC METALLOPROTEINASE BAP1, ZINC ION, (2R,3R)-N^1^-[(1S)-2,2-DIMETHYL-1-(METHYLCARBAMOYL)PROPYL]-N^4^-HYDROXY-2-(2-METHYLPROPYL)-3-{[(1,3-THIAZOL-2-YLCARBONYL)AMINO]METHYL}BUTANEDIAMIDE, ... (6 entities in total)
Functional Keywords	hydrolase inhibitor complex, metal-binding, zinc-depending, metalloprotease, metalloproteinase-inhibitor complex, zinc, toxin, secreted, protease, hydrolase, p-i snake venom metalloproteinase, metzincin, chemotaxis, adamalysin, endopeptidase, alpha-beta protein, matrixmetalloproteinase, tumor necrosis factor alpha converting enzyme, pyrrolidone carboxylic acid, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	BOTHROPS ASPER (TERCIOPELO)
Total number of polymer chains	1
Total formula weight	23452.90
Authors	Lingott, T.J.,Schleberger, C.,Gutierrez, J.M.,Merfort, I. (deposition date: 2008-10-14, release date: 2009-06-16, Last modification date: 2023-12-13)
Primary citation	Lingott, T.J.,Schleberger, C.,Gutierrez, J.M.,Merfort, I. High-Resolution Crystal Structure of the Snake Venom Metalloproteinase Bap1 Complexed with a Peptidomimetic: Insight Into Inhibitor Binding. Biochemistry, 48:6166-, 2009 Cited by PubMed: 19485419 DOI: 10.1021/BI9002315 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.08 Å)

Structure validation