2W12
High-resolution crystal structure of the P-I snake venom metalloproteinase BaP1 in complex with a peptidomimetic: insights into inhibitor binding
Summary for 2W12
Entry DOI | 10.2210/pdb2w12/pdb |
Related | 1ND1 2W13 2W14 2W15 |
Descriptor | ZINC METALLOPROTEINASE BAP1, ZINC ION, (2R,3R)-N^1^-[(1S)-2,2-DIMETHYL-1-(METHYLCARBAMOYL)PROPYL]-N^4^-HYDROXY-2-(2-METHYLPROPYL)-3-{[(1,3-THIAZOL-2-YLCARBONYL)AMINO]METHYL}BUTANEDIAMIDE, ... (5 entities in total) |
Functional Keywords | hydrolase inhibitor complex, metal-binding, zinc-depending, metalloprotease, metalloproteinase-inhibitor complex, zinc, toxin, secreted, protease, hydrolase, p-i snake venom metalloproteinase, metzincin, chemotaxis, adamalysin, endopeptidase, alpha-beta protein, matrixmetalloproteinase, tumor necrosis factor alpha converting enzyme, pyrrolidone carboxylic acid, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | BOTHROPS ASPER (TERCIOPELO) |
Total number of polymer chains | 1 |
Total formula weight | 23383.82 |
Authors | Lingott, T.J.,Schleberger, C.,Gutierrez, J.M.,Merfort, I. (deposition date: 2008-10-14, release date: 2009-06-16, Last modification date: 2023-12-13) |
Primary citation | Lingott, T.J.,Schleberger, C.,Gutierrez, J.M.,Merfort, I. High-Resolution Crystal Structure of the Snake Venom Metalloproteinase Bap1 Complexed with a Peptidomimetic: Insight Into Inhibitor Binding. Biochemistry, 48:6166-, 2009 Cited by PubMed: 19485419DOI: 10.1021/BI9002315 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.46 Å) |
Structure validation
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