2W12

High-resolution crystal structure of the P-I snake venom metalloproteinase BaP1 in complex with a peptidomimetic: insights into inhibitor binding

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1203

Chain	Residue
A	HIS142
A	HIS146
A	HIS152
A	WR21204

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site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 1205

Chain	Residue
A	PRO202
A	WR21204
A	HOH2266
A	HOH2365
A	ARG110
A	ALA111
A	GLU143
A	HIS146
A	LYS201

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Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TMAHELGHNL

Chain	Residue	Details
A	THR139-LEU148

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276

Chain	Residue	Details
A	GLU143

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:14500885, ECO:0007744|PDB:1ND1

Chain	Residue	Details
A	HIS142
A	HIS146
A	HIS152

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