2W0S

Crystal structure of vaccinia virus thymidylate kinase bound to brivudin-5'-monophosphate

2W0S の概要

• エントリーDOI: 10.2210/pdb2w0s/pdb
• 関連するPDBエントリー: 2V54
• 分子名称: THYMIDYLATE KINASE, MAGNESIUM ION, (E)-5-(2-BROMOVINYL)-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: nucleotide biosynthesis, atp-binding, nucleotide-binding, kinase, poxvirus, tmp kinase, transferase
• 由来する生物種: VACCINIA VIRUS COPENHAGEN
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 48015.85

構造登録者

Caillat, C.,Topalis, D.,Agrofoglio, L.A.,Pochet, S.,Balzarini, J.,Deville-Bonne, D.,Meyer, P. (登録日: 2008-10-08, 公開日: 2008-10-21, 最終更新日: 2023-12-13)

• 主引用文献: Caillat, C.,Topalis, D.,Agrofoglio, L.A.,Pochet, S.,Balzarini, J.,Deville-Bonne, D.,Meyer, P.; Crystal Structure of Poxvirus Thymidylate Kinase: An Unexpected Dimerization Has Implications for Antiviral Therapy; Proc.Natl.Acad.Sci.USA, 105:16900-, 2008; PubMed: 18971333; DOI: 10.1073/PNAS.0804525105

実験手法

X-RAY DIFFRACTION (2.918 Å)