2W0B

CYP51 OF M. TUBERCULOSIS BOUND TO AN INHIBITOR 3-{[(4-METHYLPHENYL)SULFONYL]AMINO}PROPYL PYRIDIN-4-YLCARBAMATE

2W0B の概要

• エントリーDOI: 10.2210/pdb2w0b/pdb
• 関連するPDBエントリー: 1E9X 1EA1 1H5Z 1U13 1X8V 2BZ9 2CI0 2CIB 2VKU 2W09 2W0A
• 分子名称: CYTOCHROME P450 51, PROTOPORPHYRIN IX CONTAINING FE, 3-{[(4-methylphenyl)sulfonyl]amino}propyl pyridin-4-ylcarbamate, ... (4 entities in total)
• 機能のキーワード: steroid biosynthesis, protein-inhibitor complex, metal-binding, oxidoreductase, lipid synthesis, nadp, iron, heme, cytoplasm, monooxygenase, sterol biosynthesis
• 由来する生物種: MYCOBACTERIUM TUBERCULOSIS
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 52443.18

構造登録者

Podust, L.M. (登録日: 2008-08-12, 公開日: 2009-01-20, 最終更新日: 2023-12-13)

• 主引用文献: Chen, C.K.,Doyle, P.S.,Yermalitskaya, L.V.,Mackey, Z.B.,Ang, K.K.,McKerrow, J.H.,Podust, L.M.; Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit.; Plos Negl Trop Dis, 3:e372-e372, 2009; PubMed: 19190730; DOI: 10.1371/journal.pntd.0000372

実験手法

X-RAY DIFFRACTION (1.56 Å)