2VZE

Crystal structure of human acyl-CoA synthetase medium-chain family member 2A (L64P mutation) in complex with AMP

2VZE の概要

• エントリーDOI: 10.2210/pdb2vze/pdb
• 分子名称: ACYL-COENZYME A SYNTHETASE ACSM2A, MITOCHONDRIAL, ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: ligase, metal-binding, transit peptide, lipid metabolism, nucleotide-binding, atp-binding, adenylate-forming enzyme, fatty acid metabolism, fatty acid-coa ligase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 191069.65

構造登録者

Yue, W.W.,Kochan, G.T.,Pilka, E.S.,Bhatia, C.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Wikstrom, M.,Bountra, C.,Oppermann, U. (登録日: 2008-07-31, 公開日: 2008-10-14, 最終更新日: 2023-12-13)

• 主引用文献: Kochan, G.,Pilka, E.S.,Delft, F.V.,Oppermann, U.,Yue, W.W.; Structural Snapshots for the Conformation- Dependent Catalysis by Human Medium-Chain Acyl- Coenzyme a Synthetase Acsm2A.; J.Mol.Biol., 388:997-, 2009; PubMed: 19345228; DOI: 10.1016/J.JMB.2009.03.064

実験手法

X-RAY DIFFRACTION (2.45 Å)