2VZ6

Structure of human calcium calmodulin dependent protein kinase type II alpha (CAMK2A) in complex with Indirubin E804

Summary for 2VZ6

• Entry DOI: 10.2210/pdb2vz6/pdb
• Descriptor: CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN, (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}, S-1,2-PROPANEDIOL, ... (4 entities in total)
• Functional Keywords: transferase, serine/threonine-protein kinase, atp-binding, cell junction, cell membrane, long term potentiation, brain, kinase, synapse, membrane, nmda receptor signalling, phosphoprotein, calmodulin-binding, nucleotide-binding
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cell junction, synapse, presynaptic cell membrane : Q9UQM7
• Total number of polymer chains: 2
• Total formula weight: 72242.84

Authors

Pike, A.C.W.,Rellos, P.,King, O.,Salah, E.,Parizotto, E.,Fedorov, O.,Shrestha, L.,Burgess-Brown, N.,Roos, A.,Murray, J.W.,von Delft, F.,Edwards, A.,Arrowsmith, C.H.,Wikstroem, M.,Bountra, C.,Knapp, S. (deposition date: 2008-07-30, release date: 2008-08-26, Last modification date: 2023-12-13)

• Primary citation: Rellos, P.,Pike, A.C.W.,Niesen, F.H.,Salah, E.,Lee, W.H.,von Delft, F.,Knapp, S.; Structure of the Camkiidelta/Calmodulin Complex Reveals the Molecular Mechanism of Camkii Kinase Activation.; Plos Biol., 8:426-, 2010; PubMed: 20668654; DOI: 10.1371/JOURNAL.PBIO.1000426

Experimental method

X-RAY DIFFRACTION (2.3 Å)