2VZ2

Human MAO B in complex with mofegiline

2VZ2 の概要

• エントリーDOI: 10.2210/pdb2vz2/pdb
• 関連するPDBエントリー: 1GOS 1H8R 1OJ9 1OJA 1OJB 1OJC 1OJD 1S2Q 1S2Y 1S3B 1S3E 2BK3 2BK4 2BK5 2BYB 2C64 2C65 2C66 2C67 2C70 2C72 2C73 2C75 2C76 2V5Z 2V60 2V61 2VRL 2VRM
• 分子名称: AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, (1Z)-4-(4-FLUOROPHENYL)-2-METHYLIDENEBUTAN-1-IMINE, ... (5 entities in total)
• 機能のキーワード: oxidoreductase, inhibitor binding, flavoprotein, mitochondrion, transmembrane, human monoamine oxidase, mitochondrion outer membrane, fad, flavin, membrane, mofegiline, acetylation
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side: P27338
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 120274.10

構造登録者

Bonivento, D.,Mattevi, A. (登録日: 2008-07-29, 公開日: 2008-12-16, 最終更新日: 2023-12-13)

• 主引用文献: Milczek, E.M.,Bonivento, D.,Binda, C.,Mattevi, A.,McDonald, I.A.,Edmondson, D.E.; Structural and mechanistic studies of mofegiline inhibition of recombinant human monoamine oxidase B.; J. Med. Chem., 51:8019-8026, 2008; PubMed: 19053775; DOI: 10.1021/jm8011867

実験手法

X-RAY DIFFRACTION (2.3 Å)